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Primordial germ cells PGCs are the embryonic precursors of gametes in the adult organism, and their development, differentiation, and survival are regulated by a combination of growth factors collectively known as the germ cell niche. Although many candidate niche components have been identified through studies on mouse PGCs, the growth factor composition of the human PGC niche has not been studied extensively. Here we report a detailed analysis of the expression of components of the bone morphogenetic protein BMP signaling apparatus in the human fetal ovary, from postmigratory PGC proliferation to the onset of primordial follicle formation. By establishing long-term cultures of human fetal ovaries in which PGCs are retained within their physiological niche, we find that BMP4 negatively regulates postmigratory PGC numbers in the human fetal ovary by promoting PGC apoptosis. Finally, we report expression of both muscle segment homeobox MSX 1 and MSX2 in the human fetal ovary and reveal a selective upregulation of MSX2 expression in human fetal ovary in response to BMP4, suggesting this gene may act as a downstream effector of BMP-induced apoptosis in the ovary, as in other systems. These data reveal for the first time growth factor regulation of human PGC development in a physiologically relevant context and have significant implications for the development of cultures systems for the in vitro maturation of germ cells, and their derivation from pluripotent stem cells. Primordial germ cells PGCs are a transient population of germline stem cells present only during embryonic development and are the precursors of sperm and egg in the adult organism [ 1 ]. PGCs arise from the proximal epiblast of the mammalian embryo [ 2 , 3 ] before migrating to and colonizing the developing gonadal ridges, during which their numbers increase substantially by mitotic proliferation.


This guidance is targeted at hospitals, medical clinics, doctors’ offices, long-term care facilities, and veterinary facilities to help decrease the amount of pharmaceuticals that are discharged to water bodies. Environmental responsibility is important to the AVMA. As part of this, the AVMA supports education of and understanding by veterinarians and the public regarding control and prevention of environmental impacts of pharmaceuticals as well as other substances.

In addition, the AVMA encourages promotion of scientifically-based, environmentally sensitive practices of veterinary medicine to ensure a viable ecosystem for future generations. The veterinary profession is a minimal contributor of pharmaceutical waste in the water systems.

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Not a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Several of the references listed above are based in part on one of the original guidelines produced for the Metropolitan Washington Council of Governments by Schueler In addition to the above references, many cities and other public agencies provide good, localized design guidelines, such as the Stormwater Management Manual provided by the Bureau of Environmental Services in Portland, Oregon BES Several methods can be employed for sizing hydrologic and hydraulic controls including flow attenuation, volume reduction, and flow duration.

Stream power and shear stress methods can also be used. At the downstream end of the catch- ment or subarea, this peak-shaving reduction is almost always accomplished simply through storage with a controlled release. The combination of storage and hydraulic outlet configuration may be adjusted through simple storage routing to achieve the desired peak reduction.

For example, storage-indication, or modified-Puls routing works well and is easily performed on a spreadsheet Bedient and Huber The greater the available storage volume, the greater the peak reduction that is possible. If the outlet capacity is too large, the hydrographs for events with peak flows under the capacity are simply passed through the storage volume with minimal reduction. After passing through the storage unit, the duration of medium flows is attenuated compared with the duration of medium flows in the incoming likely the predevelopment hydrograph.

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Our website uses Javascript for richer browsing experience. Unfortunately looks like your browser either doesn’t support Javascript or Javascript is disabled. Please enable Javascript to continue browsing. Recent work suggests that street sweeping programs can be optimized to significantly reduce pollutant washoff from urban streets.

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The Army is all set to reverse its decision to hand over the mega upgrade project of its fleet of infantry combat vehicles to the public sector. Whatever progress has been made, the issue should be resolved. But, I cannot give a guarantee to what extent it will be resolved. I want to assure that no power in the world can touch even one inch of India’s land or can occupy it,” Rajnath Singh said from a makeshift stage just a few hundred metres from the Pangong Tso lake.

There have been reports that several Indian Army soldiers were held captive by the Chinese Army following the Galwan Valley clashes in which 20 Indian Army personnel including a Colonel were killed. China has not yet released any casualty figures. At least 20 Indian soldiers were killed in a face-off with Chinese. There is no detail on the Chinese toll yet. The talks came a day after the two armies began a limited disengagement in a few areas in Galwan Valley and Hot Spring in a demonstration of their intent to ease tension along the LAC, the de-facto border between the two countries.

Addressing the BJP’s Maharashtra Jan-Samvad Rally via video link, the minister also said the Narendra Modi-led government will ensure that India’s pride is not affected as far as the situation along Indo-China border is concerned. We want to resolve it as soon as possible,” Singh said. The remarks of China’s Foreign Ministry spokesperson Hua Chunying came two days after a marathon military dialogue between India and China was held to peacefully resolve the current border standoff in accordance with bilateral agreements.

Anti-satellite weapon Shakthi, Army’s battle tank Bhishma, infantry combat vehicles and newly inducted Chinook and Apache helicopters of the Indian Air Force will be part of the grand military parade.

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The goal of the Iowa BMP Best Management Practices Mapping Project is to provide a complete baseline set of BMPs dating from the timeframe for use in watershed modeling, historic occurrence, and future practice tracking. We can’t guarantee that mapped practices meet NRCS standards or that they are actually the indicated practice since no ground truthing is being performed. In order to download data, you will be asked for some identifying information. The majority of the HUC 12 datasets will have a column indicating presence in , which is the named year of the inventory, even though data was collected from

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Sustainable Aquaculture Techniques. The demand for food must be met as the human population reaches an estimated nine billion people by the year Most of the population growth is expected to continue in underdeveloped countries with limited technologies and venues United Nations FAO As a popular high protein food source, seafood contains omega-3 fatty acids that are required for healthy human development UMD Medical Center Fish have been shown to have numerous health benefits Table 1. Seafood is a healthy, low-fat alternative to beef, poultry, and pork and significant omega-3 fatty acids much higher than vegetable-based diets FAO FOCUS Population growth and economic development trends are the most important drivers for the demand for high quality and nutritional seafood products Ewart

BMP9 stimulates joint regeneration at digit amputation wounds in mice

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Stormwater Best Management Practices in an Ultra-Urban Setting: Selection and Monitoring

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal.

A major goal of regenerative medicine is to stimulate tissue regeneration after traumatic injury. We previously discovered that treating digit amputation wounds with BMP2 in neonatal mice stimulates endochondral ossification to regenerate the stump bone. Here we show that treating the amputation wound with BMP9 stimulates regeneration of a synovial joint that forms an articulation with the stump bone.

Iowa BMP Mapping Project

Android is project promoted primarily by Google through the Open Handset Alliance aimed at providing a complete set of software for mobile devices: an operating system, middleware and key mobile applications [1]. Although the project is currently in a development phase and has not made an official release yet, several vendors of mobile chips have unveiled prototype phones built using development releases of the platform at the Mobile World Congress [2].

The Android Software Development Kit includes a fully functional operating system, a set of core libraries, application development frameworks, a virtual machine for executing application and a phone emulator based on the QEMU emulator [4]. Public reports as of February 27th, state that the Android SDK has been downloaded , times since November [5]. While some of these vulnerabilities stem from the use of outdated and vulnerable open source image processing libraries other were introduced by native Android code that use them or that implements new functionality.

Exploitation of these vulnerabilities to yield complete control of a phone running the Android platform has been proved possible using the emulator included in the SDK, which emulates phone running the Android platform on an ARM microprocessor.

JAVMA News Read news from JAVMA before it appears in print, and search archives dating back to Recalls & alerts Keep track of product alerts for pet​.

This case study is based on a study evaluating streetsweeping technology by Kurahashi and Associates, Inc. The Port of Seattle owns five cargo container yards, covering a total area of approximately ha ac , which serve its marine terminals. A major expansion effort currently under way at two of the five yards will result in a substantial increase in the container yard area.

At the present time, the only stormwater treatment BMP that is technically feasible and approved for new marine facilities is the wet vault. In May , the Port of Seattle contracted with Kurahashi and Associates to evaluate the effectiveness of new high-efficiency pavement sweepers in combination with conventional sediment-trapping catch basins to determine if the combination technology provided pollutant reduction benefits that were comparable to those of wet vaults.

The evaluation was prompted by the results of recent studies conducted by Kurahashi and Associates that indicated significant reductions in pollutant loadings could be achieved through the use of high-efficiency sweepers.

BMP for Unused Pharmaceuticals at Health Care Facilities

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How does the BMP/SMAD pathway promote SN neuronal identity? () Birth dating of midbrain dopamine neurons identifies A9 enriched.

Votes: 6. A new version of the long-running MTV reality show, which looks to unite people from different backgrounds and find a common ground. Votes: 3, Stars: Adam Lieblein , Lisa Lindo. A diverse group of five to six people in their late teens to mids are chosen to travel together in an RV, completing missions in order to receive a handsome reward. Each season’s trip takes place in a different region. Votes: The casts of the first four The Real World seasons reunite to relive old times, settle feuds, and answer questions from a studio audience.

Three past members of “The Real World” get together to reminisce about their vacations. Stars: Heather B. Votes: 7.

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